Immortal Animals and the Human Link

 

 

Since time mmemorial, humans have coveted and sought the fabled ‘fountain of youth.’  To live forever is a notion reserved for science fiction and vampire dramas, but what if it were possible? For a select few animals, immortality is a reality.

*Note: While there are various more animals that effectively resist the effects of aging, this list is only composed of animals that are thought to be truly immortal, not just long lived.

 

Hydra: 

 

Hydra are tiny creatures that can be found in most freshwater lakes, ponds, and streams.  As they are only a few millimeters long they require a microscope to be observed.  While these minuscule organisms might slip right by the naked eye, biologists and other scientists are transfixed on studying them.  The reason is that hydra don’t age, not even slightly; they are truly immortal.

The source of hydra immortality lies in their ability to maintain telomere length. Each time a cell divides, telomeres, additional strands of DNA at the end of chromosomes, shorten and get chipped away. This is what causes aging and the corrupted replication of cells in all life forms, including humans.  This aging process, or senescence as it is called in the scientific community, leads to age related illnesses such as cancer, and eventually death.  In hydra, telmores never get shorter.  Although it is unknown precisely how hydra maintain their telomere length so impeccably, recent studies have revealed that a gene called FoxO, which has a direct influence on stem cells, is likely the answer.  When FoxO activity is reduced in Hydra their powers wane and they suddenly show signs of aging.

Related Article: Immortality Formula: YOLF

This is particularly exciting because FoxO is also responsible for stem cell activity in humans.  Greater FoxO activity is routinely found in people with abnormally long lifespans, like centenarians. It may be possible to increase FoxO activity from an early age, maintain levels of stem cells in the body, and thus increase human lifespan by 1000’s of years; maybe even forever.

 

Jellyfish:

 

Jellyfish come in all shapes and sizes, but one particular jellyfish is especially baffling; the immortal jellyfish.  Technically called Turritopsis nutricula, the immortal jellyfish has the ability to, at any strage of its life, completely reverse its aging process.

Jellyfish begin as small polyps on the ocean floor. These polyps branch off and eventually grow into medusas, or sexually mature jellyfish, with tentacles and the traditional jellyfish-look we all know and adore.  The immortal jellyfish holds the title of being the only animal with the ability to revert back into a sexually immature state after being sexually mature.  The medusa form of the immortal jellyfish reverses the aging process through a method known as cell transdifferentiation.  This process transforms cells into a different cellular state, including earlier states. As the cells transform, the medusa retracts its tentacles and head into itself, turns back into a polyp, embeds itself back into the ocean floor, and starts life all over again.

For some human perspective, imagine all the cells in your body suddenly transforming into stem cells as your body shrinks and reverts back into an infantile state. From deathbed to birthing room in the blink of an eye.

Related Article: Aging Process is Similar to Replicating CDs: Story of Telomeres

Interestingly, immortal jellyfish have a choice to drink from the fountain of youth or not.  While some jellyfish reset life early on, others choose to brave the struggle of old age and eventually die without the opportunity for a second chance. Who can really blame them though?  Without Wondergressive or pirated entertainment, what’s the point of living?

 

Lobsters:

 

Lobsters, the hallmark of a luxury dinner and recently discovered abundant power source, are also immortal. While scientists have never found a 10,000 year old lobster lurking on the ocean floor, at the cellular level, they age at a negligible rate.  As long as lobsters are not hunted, fatally injured, or killed by disease, they could live indefinitely. It gets even stranger, as lobsters become more fertile as they age:

They don’t slow down or become weaker or more susceptible to disease. They don’t get infertile — older  lobsters are actually more fertile than younger ones.

This is unprecedented!  Ladies, can you imagine getting menopause out of the way when you are 10 and being at the height of your sexual activity when you are 90?  Welcome to the life of a lobster.

Related Article: Cyborg Lobsters Power a Digital Watch

Scientists believe that like hydra, lobsters are able to beat the aging process through the maintenance of its telomeres, as lobsters produce a large amount of telomerase, the enzyme responsible for ensuring the health and longevity of telomeres.

As lobsters age, they continue to grow larger and larger, making it easy to guess the age of a lobster based on its size.  The largest recorded lobster ever caught was in Nova Scotia, Canada, weighed 44.4 lbs and was believed to be 50 years old.

 

Planarian Flatworms:

 

Planarian flatworms are non-parasitic worms that are found all over the world; in saltwater, freshwater, soil, and more. They are very common, and come in the asexual and sexual variety, take your pick.  No matter which type you choose, you’ll still be choosing another immortal animal.

Related Article: Fly Away Home: Birds Evolve With Automobile Traffic

Through plentiful adult stem cells and a high production of telomerase, planarian flatworms have an infinite regenerative ability.  This incredible regeneration applies not only to the general maintenance of its body, but also to an unprecedented level of repair in the event of physical damage.

Planaria can be cut into pieces, and each piece can regenerate into a complete organism. Cells at the location of the wound site proliferate to form a blastema that will differentiate into new tissues and regenerate the missing parts of the piece of the cut planaria.

1/279th of a piece of planarian flatworm can be cut from its body and will grow into a new, completely independent flatworm within a few weeks.  You can slice and dice this animal into hundreds of pieces and you’ll just be left with more worms!

Related Article: The Most Dangerous Animal and How We Can Defeat It

Even more interestingly,

if the head of a planaria is cut in half down its centre, and each side retained on the organism, its possible for the planaria to regenerate two heads and continue to live.

Imagine if every time you cut yourself shaving a mini-you started writhing and growing in the sink.  In this way, the planarian flatworm can continuously regrow itself and remain immortal through countless copies.

 

Tardigrades:

 

Tardigrades are also called waterbears, or moss piglets, because under a microscope, that’s exactly what they look like. They are one of the most well known extremophiles; animals that can survive under conditions fatal to most other forms of life.  They are usually around 1 millimeter in length and can be found absolutely everywhere on the planet, from common streams, to moss in your backyard, to the top of the Himalayas, and even in newly discovered ecosystems.  They prefer places with lots of moisture, but as you’ll soon see, it really doesn’t matter to them where they live.

Related Article: New Ecosystem Discovered: Glacier Mice

Although Tardigrades aren’t immortal in the same sense as the animals listed above, they have the incredible ability to survive in nearly every environment known to man, including the vacuum of space, by entering a state of suspended animation called cryptobiosis where their metabolism reaches near zero.  They can stay in this state for more than ten years, return to normal, and go right back into the suspended state for another 10 years of rest and relaxation.  They are their own cryogenic tanks.

 

Tardigrades have been observed surviving extreme conditions such as:

  1. Temperatures above 300 F

  2. Temperatures lower than -328 F

  3. Pressure of more than 6,000 atmospheres (six times the pressure of water in the Mariana trench)

  4. More than 10 years without water

  5. Extremely lethal human doses of gamma, heavy ion, and UV radiation

  6. The vacuum of space

Tardigrades are naturally indestructible, and if they desire to be, are also immortal.
All of these animals and their remarkable anti-aging abilities are creating new opportunities for scientists to actually discover and synthesize the ‘fountain of youth.’  In fact, many prominent scientists believe that the solution(s) to old age and even death is right around the chronological corner.  According to Aubrey de Grey, a British researcher on aging and life extension, the first human being to live to 1000 years old has already been born. It might even be you…

 

 

Source List:

BBC Nature: Nature’s Guide to Immortality 

UCI.edu: Senescence in Hydra

Wondergressive: Telomere and Aging

PNAS: FoxO is a critical regulator of stem cell maintenance in immortal Hydra

Extreme Longevity: Hydra Immortality Linked to Human Lifespan 

Developmental Biology: The Immortal Life Cycle of Turritopsis

JSTOR: Reversing the Life Cycle

Cell Transdifferentiation 

Wondergressive: Hollywood is Pirating Hollywood

Wondergressive: Cyborg Lobsters Power a Digital Watch 

HowStuffWorks: 400 Pound Lobster

Telomeres and Cellular Aging

Guinness World Records: Heaviest Marine Crustacean

Encyclopedia Britannica: Planarian 

PubMed: Planarian Regeneration

PubMed.gov: Stem Cells and Regeneration in Planarians

NewScientist: Regenerating Animals

Wondergressive: New Ecosystem Discovered: Glacier Mice 

Youtube: Tardigrades First Animal to Survive in Space

IWU.edu: Tardigrades 

Journal of Zoology: Longterm Anhydrobiotic Survival

Survival of Tardigrades in Extreme Environments

Current Biology: Tardigrades Survive Exposure to Space

Nature: Preserving Tardigrades Under Pressure

PubMed.gov: Radiation Tolerance in the Tardigrade

Discovery.com: Immortal Animals Reveal Anti-aging Secrets

TED: We Can Avoid Aging

Additional Related Resources:

Wondergressive: Cannabis Cures Cancer and Everything Else: A Thorough History and Review

Wondergressive: Obesity and Low-Carb Fads 

Wondergressive: The Great Vitamin D-ficiency 

Wondergressive: Green Tea Health

Wondergressive: Low-carb/Low-calorie Diet Produces Compound That Blocks the Effects of Aging

Wondergressive: The Wonderful, Healthier, Life Changing and Life Lengthening World of Fasting

 

Red Wine Vinegar Aids Weight Loss and Fights Diabetes

 

Red Wine Vinegar goes well with salads and is a staple of the Mediterranean cuisine. But did you know that it can also help you lose weight and curb your appetite? It even allows you to eat the high-carb foods that usually give you a feeling of regret after the last bite.

When red wine is fermented for a long period, it transforms into red wine vinegar. Besides containing the same antioxidant called resveratrol, the main component of red wine vinegar, and the one that gives it the sour taste, is acetic acid.

Acetic acid is also a main component of other vinegars like white vinegar and apple cider vinegar. Acetic acid helps to slow down the digestion of foods that you eat. This action helps to regulate blood sugar and prevent spikes. Blood sugar spikes are what make your pancreas secrete insulin, which tells your body to start to store fat.

According to Doctor Oz, two tablespoons of red wine vinegar will give you optimal results if you want to maintain steady blood glucose and insulin levels. The main reason why it does so is because it prevents some of the carbohydrates that you consume from passing through the blood stream. Carbohydrates are what raise your blood sugar level, insulin level, and ultimately bring your body to store more fat. It is the carbohydrates, not the fat that you eat, that is making you fat.

Here is an excerpt from a research article summary on WebMD concerning mice and red wine vinegar:

Researchers found that the mice developed a lot less body fat (up to 10% less) than mice who didn’t receive the vinegar compound. The amount of food eaten by the mice was not affected.

It’s believed that acetic acid turns on genes that produce proteins that help the body break down fats. Such an action helps prevent fat buildup in body, and thwarts weight gain.

Diabetes is a condition in which the body cannot regulate blood sugar (blood glucose) properly. Those diagnosed with diabetes, are often told by doctors to stay away from sugary foods. This includes grains, especially bread. Carbohydrates are complex sugars, that can be broken down into simple sugars and processed by the body. As mentioned above, carbohydrates make your blood sugar and insulin sky rocket. Consuming a tablespoon or two of red wine vinegar could help some individuals with diabetes have a sugary meal without having their blood sugar levels spike abnormally. Of course, if you are diabetic, make sure you talk to your doctor before you make bagels your new food staple.

If you like your bread, pasta, bagels, and cereals, then incorporating red wine vinegar into your diet could aid in the slowing of digestion and subsequent weight loss. As a spritzer or as a salad dressing, red wine vinegar can be quite delicious.

Get your own bottle of our favorite red wine vinegar over at Amazon.

 

Sources:

Crush Your Cravings With 5 Appetite-Suppressing Foods

NewsMedical.net- What is Resveratrol

http://www.ncbi.nlm.nih.gov/pubmed/23265476

WebMD- Causes of Type 2 Diabetes

WebMD- Vinegar May Aid in Fat Loss

Mayo Clinic- Definition of Diabetes

 

Extra Reading: 

DailyMail.co.uk- The Healing Powers of Vinegar

LiveStrong.com- The Health Benefits of Red Wine Vinegar

Japanese Diet Secret: Black Soybean Tea (Kuromame Tea)

black soybean kuromame

Kuromame Black Soybean Tea http://www.hirokoskitchen.com

 

Black soybean tea, otherwise known as kuromame tea, is another wonderful secret of how the Japanese maintain their weight and health. Obesity is arguably the worst health risk threatening the developed world, especially in the West. According to the Centers for Disease Control and Prevention, more than one third, or 35.7%, of American adults, are obese. More than two-thirds of adults are considered overweight.

Kuromame tea is here to help you, if not save you. Kuromame, or black soybeans, a rare legumes native to China, and have long been used in Chinese medicine to clear toxins from the body and promote urination. Kuromame has also been linked to effective weight loss along with promoting a healthy diet. There are a few major components to black soybean kuromame tea that give it its remarkable fat shedding ability.

Related Article: Japanese Diet Secret: Kurozu (Black Vinegar)

 

Polyphenols in Black Soybean Kuromame Tea

Polyphenols are compounds known for their anti-aging properties. They are found in foods such as black rice, pears, and potatoes. Black soybeans contain a specific polyphenol called anthocyanin which is known to fight numerous human diseases. Anthocyanin has shown positive results in cancer prevention, anti-aging, reducing the risk of arteriosclerosis, lowering cholesterol, and promotion of lipid metabolism.

A study done by the Journal of Medicinal Food found that anthocyanin inhibited fat absorption in a group of mice that included a higher amount of fat in their diet compared to the control group. The mice did not gain any additional weight.

 

Isoflavones and Weight Loss

Isoflavones are themselves a type of anti-oxidant and help prevent certain types of cancer such as breast cancer. They also improves lipid metabolism. Lipid metabolism powers your weight loss, or more specifically fat loss. Kuromame tea can help you with this because black soybeans are filled with isoflavones. Lipid metabolism is the process of your body fat being mobilized to be used as energy. They also help to control circulatory blood fats.

There are two more very important components to black soybeans that make kuromame tea the choice for a healthier diet and effective weight loss. One is fiber. Black soybeans are a high carbohydrate legume. However, a large portion of  those carbohydrates come from fiber. Fiber helps to lower cholesterol and helps prevent a steep rise in blood sugar levels. The other important and not commonly known compound found in kuromame skin is saponin. Saponin is a chemical compound that also inhibits the absorption of fat.

 

Make Your Own Black Soybean Kuromame Tea

I have been making my own kuromame tea from the black soybeans I buy in the Asian markets near my house (which you can also buy on Amazon). There is really not much to it:

You grab a handful of black soybeans and put them in a pan over high heat. Let them roast for a few minutes. Nothing extra has to be added. Boil some water for later use. The black soybeans will be ready once you hear the skin crack and the color of the beans turns brown. Take the beans and put them in a french press or other utensil you normally use to prepare tea. Pour in the boiling water and let it sit for a few minutes, or let it sit until you are done drinking.

The reason I do not put down specific measurements is because you can adjust the amount of water to your own liking. Some people like kuromame tea with a smokier taste and some like it more diluted.

After drinking, you can eat the black soybeans themselves since they will be nice and soft. This way you can take in all of the healthy carbs and fiber available to you. It is also worth mentioning that black soybeans are low on the glycemic index, so they make a perfect snack for diabetics!

 

 

Sources:

Wondergressive: The Obese Shall Inherit the Earth

http://www.livestrong.com/article/305656-calories-in-black-soybeans/

http://www.japantimes.co.jp/community/2000/07/03/general/its-a-drink-and-a-snack-black-soybeans/#.UYCFjbWG1rM

http://slism.com/diet/black-bean-diet.html

http://online.liebertpub.com/doi/abs/10.1089/jmf.2006.147

http://www.cdc.gov/obesity/data/adult.html

http://win.niddk.nih.gov/statistics/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082894/

http://www.med.unc.edu/neurology/files/documents/child-teaching-pdf/OVERVIEW%20OF%20LIPID%20METABOLISM.pdf

http://ir.library.oregonstate.edu/xmlui/handle/1957/33070

http://www.health.harvard.edu/newsweek/Glycemic_index_and_glycemic_load_for_100_foods.htm

 

Recommended Reading for those Interested in More Japanese Secrets

Japanese Farm Food

Autophagy: The Unsung Hero in Slowing Down Aging

 

We’ve been told that antioxidants and resveratrol are the way towards fighting age related diseases, but most people know little about the autophagy process and how beneficial it is to sustaining healthy cells and increasing their survival. Autophagy is the cell repair mechanism that recycles unused or damaged cell components. Here is a better explanation from PubMed:

Autophagy is a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress. Autophagy also plays a housekeeping role in removing misfolded or aggregated proteins, clearing damaged organelles, such as mitochondria, endoplasmic reticulum and peroxisomes, as well as eliminating intracellular pathogens. Thus, autophagy is generally thought of as a survival mechanism.

 

What this means is autophagy plays a crucial role in maintaining healthy cells, and down regulating it is thought to be one of the main reasons for cell damage and AGING. The truth is that we are just a walking hunk of cells that are sewn together into a four limbed oddity.

The most common form of autophagy is called macroautophagy. The way that this autophagy process works is as follows:

The most well-known mechanism of autophagy involves the formation of a membrane around a targeted region of the cell, separating the contents from the rest of the cytoplasm. The resultant vesicle then fuses with a lysosome and subsequently degrades the contents.

So in the process of macroautophagy your cells are protected and cleaned, leaving them healthy and toxin free.  If you want to learn more about this amazing gem in the constant search for anti-aging methods, please look into these related reads:

Autophagy: cellular and molecular mechanisms

Autophagy and Aging: The Importance of Maintaining “Clean” Cells

 

Sources:

Autophagy

Resveratrol

What is Autophagy?

Wondergressive: Anti-aging Articles

 

Balls of Fury: Eunuchs Live Longer?

Source: http://cl.jroo.me, via Google

Ouch. There has to be a better way.

A report in the scientific journal Current Biology shows a very interesting find: eunuchs live longer than their ball-carrying brethren. Balls-deep into the archives from the Imperial Court of the Korean Chosun dynasty (1392–1910), Korean researcher Kyung-Jin Min found that castrated men of the era lived to be 70 years of age, significantly longer than the average age of 47. Even more astonishing was that three of the 80 men lived to be 100 years old. Given the population at the time, that’s 130 times more centenarians than even the most-developed countries of today.

The men were castrated as boys, which suggests that hormones may play a factor in why men don’t live as long as women. They never got to experience that wonderful, pimply and oily part of life – puberty. Dr. L. Stephen Coles, a co-founder of the Los Angeles Gerontology Research Group, has a theory on why this matters:

Females may have an advantage in longevity because they have a back-up X chromosome. A woman’s body is a mixture of cells, half containing an active X chromosome from her mother and the other half from her father. If there is a defect on one X chromosome, half of her cells will be unaffected.

Makes sense. If we have an ailment that originates in our DNA, women have another copy of the gene. In the IT world, we call that a backup plan.

Head over to the source links for more information. With all that said, I think I’ll stick with what I’ve got…

Sources: Reuters, TIME/CNN, BBC